microfluidic pump fusion 100  (Chemyx Inc)

Journal: Pharmaceutics

Article Title: 3D Printed Microfluidic Devices for Drug Release Assays

doi: 10.3390/pharmaceutics13010013

Figure Lengend Snippet: Overhead and side view schematic illustration of “V” (left) and “basket” (right) shape dissolution microfluidic chip. The overall dimensions of the “V” and “basket” shape chips are identical with a main chamber width ( A ) of 16 mm, length ( B ) of 20 mm and height ( C ) of 600 µm. Both chips contain a downstream trap of 38 teeth separated by 120 µm gaps ( D ). “V” trap design (left): includes two trapezoids separated by 120 µm gap ( E ). The V traps are lined in six rows of on and off seven and eight traps, with a 1 mm gap between traps ( F ) and separated by 2.4 mm gap ( G ). “Basket” trap design (right): includes four rectangular teeth and additional two diagonal triangular teeth placed on both sides, separated by 120 µm gaps ( H ) creating a 1.2 mm depth ( I ).

Article Snippet: For the drug release assays, microfluidic dual syringe pumps (Chemyx Fusion 100 Stafford, TX, USA) were used.

Techniques:

Journal: Pharmaceutics

Article Title: 3D Printed Microfluidic Devices for Drug Release Assays

doi: 10.3390/pharmaceutics13010013

Figure Lengend Snippet: DOX-microsphere (MS) schematic preparation protocol. ( A , B ) The solid phase (DOX+PLA) was prepared using a “bain-marie” setup. ( C ) DCM was added and dissolved on the drug-polymer film, ( D ) followed by homogenization with DDW or 1% ammonium bicarbonate (ABC) solution. Finally, the homogenized emulsion was introduced into the microfluidics-focused flow chip platform or instantly poured into 200 mL of 1% PVA to fabricate solidified MS.

Article Snippet: For the drug release assays, microfluidic dual syringe pumps (Chemyx Fusion 100 Stafford, TX, USA) were used.

Techniques: Homogenization

Journal: Pharmaceutics

Article Title: 3D Printed Microfluidic Devices for Drug Release Assays

doi: 10.3390/pharmaceutics13010013

Figure Lengend Snippet: Characterization of DOX-loaded MS fabricated via microfluidic and batch methods. Mean diameter, encapsulation efficiency (EE) and drug content are presented as mean ± standard deviation (SD; n = 3). DOX-PMS (doxorubicin porous microspheres) DOX-NPMS (doxorubicin non-porous microspheres).

Article Snippet: For the drug release assays, microfluidic dual syringe pumps (Chemyx Fusion 100 Stafford, TX, USA) were used.

Techniques: Standard Deviation

Journal: Pharmaceutics

Article Title: 3D Printed Microfluidic Devices for Drug Release Assays

doi: 10.3390/pharmaceutics13010013

Figure Lengend Snippet: Set-up of the two geometries of 3D printed drug release microfluidic chips connected to the pump. Parallel assays can be performed simultaneously for different chip geometries or for different drug formulations. Once assembled, the system is maintained in 37 °C.

Article Snippet: For the drug release assays, microfluidic dual syringe pumps (Chemyx Fusion 100 Stafford, TX, USA) were used.

Techniques:

Journal: Pharmaceutics

Article Title: 3D Printed Microfluidic Devices for Drug Release Assays

doi: 10.3390/pharmaceutics13010013

Figure Lengend Snippet: Combined fluorescence and bright-filed microscopy image of a “V” and “basket” shape mechanical barrier. ( A ) . Magnified view of a single polymeric microsphere captured in a ‘V’ trap design. ( B1 , B2 ) . DOX-PMS captured in the “basket” trap design. ( C ) . Trapped DOX-PMS in final pillar barriers before the outlet tube. ( D ) Lyophilized microfluidic based DOX-PMS.

Article Snippet: For the drug release assays, microfluidic dual syringe pumps (Chemyx Fusion 100 Stafford, TX, USA) were used.

Techniques: Fluorescence, Microscopy